Reviewed by PeptideGuide Research Team|Last updated February 15, 2026
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Semaglutide vs Exenatide
Complete side-by-side comparison of Semaglutide and Exenatide.
Side-by-Side Comparison
Property
Semaglutide
Exenatide
Name
Semaglutide
Exenatide
Peptide Class
Glucagon-like peptide-1 (GLP-1) receptor agonist
Incretin mimetic
Category
Weight Loss and Metabolic
Weight Loss and Metabolic
Dosage Range
0.25 mg to 2.4 mg weekly
5-10 mcg twice daily
Half-Life
Approximately 7 days
2.4 hours
FDA Status
Approved for Type 2 Diabetes and Weight Management
Approved
Safety Rating
Prescription Required
Prescription Required
Cost Estimate
$800-1200/month
$300-500/month
Semaglutide
Semaglutide is a GLP-1 receptor agonist primarily used for managing type 2 diabetes and aiding in weight loss. It works by mimicking the GLP-1 hormone...
View full profile →Exenatide
Exenatide is a synthetic peptide that mimics the incretin hormone GLP-1, primarily used for managing type 2 diabetes and aiding in weight loss. It wor...
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